Heart Rate Variability

Heart Rate Variability (HRV) uses time domain, frequency domain, and non-linear models to analyze a continuous period of heart rate changes, which have been shown in past research as a valuable clinical marker. Heart rate variability can also predict risk of cardiovascular disease. We have used HRV analysis to investigate topics regarding community and occupational health.


1. Cardiac Autonomic Modulation during on-Call Duty under Working Hours Restriction.

Chien JW, Chen CY, Lin SH, Lin SW, Lin YH.
Int J Environ Res Public Health. 2020 Feb 10;17(3).

2. Viral infection, psychopathology, and autonomic modulation among methadone users in Taiwan.

Huang WL, Chang LR, Kuo TBJ, Lin YH, Yang JL, Chen YZ, Yang CCH.
Heroin Addiction and Related Clinical Problems. 2017;19(6):31-38.

3. Novel application of multi dynamic trend analysis as a sensitive tool for detecting the effects of aging and congestive heart failure on heart rate variability.

Lin YC, Lin YH, Lo MT, Peng CK, Huang NE, Yang CC, Kuo TB.
Chaos: An Interdisciplinary Journal of Nonlinear Science. 2016 Feb;26(2):023109.

4. Impact of antipsychotics and anticholinergics on autonomic modulation in patients with schizophrenia.

Huang WL, Chang LR, Kuo TB, Lin YH, Chen YZ, Yang CC.
Journal of clinical psychopharmacology. 2013 Apr;33(2):170-7.

5. Gender differences in personality and heart-rate variability.

Huang WL, Chang LR, Kuo TB, Lin YH, Chen YZ, Yang CC.
Psychiatry research. 2013 Oct 30;209(3):652-7.

6. Gender differences in cardiac autonomic modulation during medical internship.

Lin YH, Chen CY, Lin SH, Liu CH, Weng WH, Kuo TB, Yang CC.
Psychophysiology. 2013 Jun;50(6):521-7.

7. On-call duty effects on sleep-state physiological stability in male medical interns.

Lin YH, Ho YC, Lin SH, Yeh YH, Liu CY, Kuo TB, Yang CC, Yang AC.
PloS one. 2013 Jun 4;8(6):e65072.

8. Methadone-mediated autonomic functioning of male patients with heroin dependence: the influence of borderline personality pattern.

Huang WL, Lin YH, Kuo TB, Chang LR, Chen YZ, Yang CC.
PLoS One. 2012;7(5):e37464.

9. Cardiac autonomic modulation during methadone therapy among heroin users: a pilot study.

Chang LR, Lin YH, Kuo TB, Ho YC, Chen SH, Wu Chang HC, Liu CM, Yang CC.
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2012 Apr 27;37(1):188-93.

10. Autonomic modulation and health-related quality of life among schizophrenic patients treated with non-intensive case management.

Chang LR, Lin YH, Kuo TB, Wu Chang HC, Liu CM, Liu CC, Hwu HG, Yang CC.
PLoS One. 2011;6(11):e26378.
NHRI Digital Biomarkers Lab
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